GlycoMimetics has designed and synthesized a family of compounds that target both E-Selectin and CXCR4. CXCR4 has been successfully targeted by the approved drug perixaflor, which is marketed by Sanofi as Mozobil. The drug has been approved for use to improve stem cell mobilization for transplant and is in clinical trials for use in combination with chemotherapy in hematological malignancies (types of cancer that affect blood, bone marrow, and lymph nodes). Thus, targeting CXCR4 has demonstrated clinical benefit in certain settings. Also, data presented at the December 2011 American Society of Hematology (ASH) meeting has shown in a model of acute myeloid leukemia (AML) that compounds from this compound family, combined with chemotherapy, enhanced clearance of blast cells from the bone marrow, compared to chemotherapy alone.
Combining E-Selectin and CXCR4 targeting in a single molecule may provide next-generation opportunities following on the success of Mozobil and other potential drugs in this class, particularly for treatment of certain blood cancers.
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