GlycoMimetics has reported topline results in its Phase 2 clinical trial studying its lead investigational drug GMI-1070 in vaso-occlusive crisis (VOC) of sickle cell disease.
About Sickle Cell Disease
Sickle cell disease is one of the most prevalent genetic disorders, affecting between 80,000 and 100,000 people in the U.S. alone. It is a chronic condition with substantial illness and death, responsible for more than 75,000 hospitalizations per year in the U.S. One of the most debilitating effects of sickle cell disease is vaso-occlusive crisis (VOC), where changes in blood protein cause red blood cells to become rigid and stick inside small blood vessels. This causes blockages in blood flow and results in pain, which can require medical care and hospital stays for pain medication. Other medical problems can also occur during vaso-occlusive crisis, which can complicate treatment and lead to longer hospital stays.
Clinical Trial of GMI-1070 for Treatment of Vaso-occlusive Crisis of Sickle Cell Disease
GlycoMimetics, Inc. is studying “vaso-occlusive crisis of sickle cell disease” as the first potential treatment focus for its lead investigational drug candidate. GMI-1070 is intended to treat vaso-occlusive crisis by reducing the cell adhesion and inflammation that is believed to contribute to blocking blood flow. GlycoMimetics is evaluating if this may reduce the pain experienced by individuals during sickle cell crisis and shorten their time in the hospital. GlycoMimetics is also studying whether this may reduce other medical problems that result from blood flow blockages.
GMI-1070 has received Orphan Drug status and Fast Track status from the U.S. Food and Drug Administration (FDA), which may lead to speedier delivery to people living with sickle cell disease, if the treatment is found to be effective.
In January 2013, GlycoMimetics, Inc. announced it had completed enrolling patients in a Phase 2 sickle cell disease trial with GMI-1070. GlycoMimetics enrolled 76 patients ages 12 to 65 at 22 trial sites in the United States and Canada. The company reported topline data from the trial in April 2013.
For More Information
GlycoMimetics posts information for all ongoing clinical trials on the National Institutes of Health’s (NIH) clinicaltrials.gov website. To learn more about GlycoMimetics’ clinical trial for GMI-1070 and who may be eligible to participate in the study, please visit http://clinicaltrials.gov/ct2/show/NCT01119833?term=glycomimetics&rank=1 or email: email@example.com.
For Community Organizations
GlycoMimetics, Inc. is committed to partnering with those affected by sickle cell disease and the organizations that support them. To receive information about the GMI-1070 trial, please click on this link: Information for Sickle Cell Disease Community Organizations »