GMI Abstracts and Publications:

Magnani, John. "The discovery, biology, and drug development of sialyl Le^a and sialyl Le^x." Arch. Biochem. Biophys. 2004: 426(2), p. 122-131.

Rinnbauer, Meike, Beat Ernst, Bea Wagner, John Magnani, Andrew J. Benie and Thomas Peters. "Epitope mapping of sialyl Lewis^x bound to E-selectin using saturation transfer difference NMR experiments." Glycobiology 2003: 13, No. 6 435-43.

Thoma, Gebhard, Rudolf O. Duthaler, John L. Magnani, and John T. Patton. "Nanomolar E-Selectin Inhibitors: 700-Fold Potentiation of Affinity by Multivalent Ligand Presentation." J. Am. Chem. Soc. 2001; 123(41), 10113 - 10114.

Thoma, Gebhard, Willy Kinzy, Christian Bruns, John T. Patton, John L. Magnani, and Rolf Bänteli. "Synthesis and Biological Evaluation of a Potent E-Selectin Antagonist." Journal of Medicinal Chemistry 1999: 42, 4909-13.

Thoma, Gebhard, John L. Magnani, John T. Patton, Beat Ernst, and Wolfgang Jahnke. "Preorganization of the Bioactive Conformation of Sialyl Lewis^x Analogues Correlates with Their Affinity to E-Selectin." Angewandte Chemie International Edition 2001: 40, No. 10, 1941-5.

Thoma, Gebhard, Rolf Bänteli, Wolfgang Jahnke, John L. Magnani, and John T. Patton. "A Readily Available, Highly Potent E-Selectin Antagonist." Angewandte Chemie International Edition 2001: 40, No. 19, 3644-7.

Bänteli, Rolf, Peter Herold, Christian Bruns, John T. Patton, and John Magnani. "Potent E-Selectin Antagonists." Helvetica Chimica Acta 2000: 83, 2893-907.

Thoma, Gebhard, John L. Magnani, and John T. Patton. "Synthesis and Biological Evaluation of a Sialyl Lewis X Mimic with Significantly Improved E-Selectin Inhibition." Bioorganic & Medicinal Chemistry Letters 2001: 11, 923-5.

General articles about glycobiology:

02.23.04 Time Magazine - The Fires Within
Suddenly, inflammation has become one of the hottest areas of medical research. [... C]hronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age. This concept is so intriguing because it suggests a new and possibly much simpler way of warding off disease. Instead of different treatments for, say, heart disease, Alzheimer's and colon cancer, there might be a single, inflammation-reducing remedy that would prevent all three.

09.20.03 Signals Magazine - Glycobiology: Biotech's New Sweet Spot
Research scientists have known for decades that biological organisms use carbohydrates in a number of ways – including as an energy source and as structural material. They've also recognized that proteins and cell surfaces are loaded with sugar groups – although they once thought that these moieties were merely decoration and served no important function. Well, they couldn't have been farther off base.

02.01.03 MIT Technology Review - 10 Emerging Technologies That Will Change the World
Glycomics. James Paulson, a researcher at the Scripps Research Institute in La Jolla, CA, lifts a one-liter, orange-capped bottle from his desk. The bottle is filled with sugar, and Paulson estimates that, had the substance been purchased from a chemical supply house, it would have cost about $15 million.

10.26.02 New Scientist - Sugar Rush
Once dismissed as mere decoration, sugar molecules turn out to be vital components in life's intricate machinery. Now the race is on to exploit them, says Karen Schmidt.

07.01.02 Scientific American - Sweet Medicines
Sugars play critical roles in many cellular functions and in disease. Study of those activities lags behind research into genes and proteins but is beginning to heat up. The discoveries promise to yield a new generation of drug therapies.

04.29.02 The Scientist - Glycobiology Goes to the Ball
New federal funding, new technologies, and a better understanding of carbohydrates' role in biology have scientists pondering the feasibility of a Human Glycome Project.

04.13.02 Science News Online - The True Sweet Science
"A spoonful of sugar helps the medicine go down," sings Julie Andrews in the popular Disney movie Mary Poppins. The musical nanny doesn't seem to realize that sometimes the sugar is the medicine.

01.01.02 Immunity - Developing a Taste for Sweets
Lymphocytes are covered with sugars. Some of the oligosaccharides on lymphocytes may be recognized by specific lectins such as the selectins, but what other functions do all of these oligosaccharides serve? Two recent papers in Cell(Moody et al., 2001) and Immunity(Daniels et al., 2001) describe a novel role for glycosylation in the thymus—regulating the interaction of MHC class I molecules with CD8 during thymocyte maturation.

10.01.01 Nature - The bittersweet promise of glycobiology
Carbohydrates play a wide range of important roles in the body and, despite the challenges posed by glycobiology, are now tempting targets for drug developers.

These articles appear on web sites outside of glycomimetics.com. Clicking on their associated links will open the article in a separate browser window.

Special permission is required from the publisher to view the full text of the article.